A group of US and Canadian researchers conducted the largest-scale testing of folding stability for computationally designed proteins. More than 15,000 newly designed small proteins were tested for correlation between folding and function which resulted in significant protein modeling improvements.
CRISPR (Clustered Regularly Interspaced Palindromic Repeats) gene editing technology allows permanent modification of genes within organisms. It is considered a breakthrough in biotechnology ever since its discovery. Researchers from the University of Copenhagen (Denmark), led by Spanish researcher Guillermo Montoya, now went one step further. They discovered how Cpf1, a new type of molecular scissors, unzip and cleave DNA.
Researchers from the University of Birmingham discovered an unsettling link between a major mechanism of antibiotic resistance in bacteria and triclosan, a disinfectant commonly found in household cleaning products.
Scientists from the University Of Geneva (UNIGE) and the University of Basel have created artificial viruses that can be used to target cancer. This virus is fashioned to act as an alarm for the immune system and instigate killer T cells to fight the tumour.
US researchers just discovered a novel gene associated with amyotrophic lateral sclerosis (ALS) that compromises motor neuron function in mice and zebrafish. The UBQLN4 genetic variant impairs nerve development through the excessive accumulation of beta-catenin, a realization that opens a new window for targeted treatment of ALS.
The molecular mechanisms that cause rare species of mushrooms to glow in the dark have baffled scientists for years. A new study set to finally uncover the mystery behind their bioluminescence revealed that it is in fact based on luciferin oxidation, the same chemical process used by fireflies.
Researchers at Harvard University developed an effective personalized cancer vaccine that seems to have prevented early tumour relapse in 12 skin cancer patients. The vaccine targeted 20 tumour-specific proteins unique to each of the patients enrolled, keeping all free of cancer over 2 years after the trial.
An international consortium of scientists have found a way to produce a semi-synthetic strain of baker´s yeast with more than a third of its chromosomes artificially synthesized.
A new breast cancer drug combination significantly shrunk and eliminated tumours in 28% of women tested in just 11 days. The novel treatment involves a combination of pre-chemotherapy drugs lapatinib and trastuzumab that target HER2-positive tumours.