Researchers have taken an interest in a euphorbia plant growing in Marocco as a possible painkiller. The plant’s active ingredient, resiniferatoxin (RTX), is extremely spicy, a 10,000 times hotter than the world’s hottest pepper. RTX is a potent analog of capsaicin, the active ingredient in chilli peppers, and has numerous benefits over existing painkillers. It doesn’t require frequent dosing, targets only the areas causing pain, and doesn’t produce a potentially addictive high. All this makes it a promising candidate for the clinics.
An international team of researchers detected a vast sixty-nine pharmaceutical compounds in stream insects. When these insects emerge as flying adults, they can pass these drugs further to spiders, fish, birds, bats, and other streamside foragers. This way, drug pollution moves up food webs and in some cases exposes even top predators to therapeutically-effective doses.
A group of major American hospitals established a nonprofit generic drug company, Civica Rx, to battle long-lasting shortages of critical medicines and their high prices. Their goals are providing stable supplies for 14 generic drugs used in hospitals and price transparency. This will allow hospitals to save time and money while providing patients with better health care.
Men are still limited to only a few forms of birth control. Scientists are making constant progress but the birth control pill or any other hormonal contraceptives for men are still years away from being safe, reversible, and broadly available. In the past, low demand and focus on women contraceptives partly limited development. Now, more and more men want to take control over their own fertility.
Researchers from Indiana University (IU) have made the first direct visual observation of bacteria taking up foreign DNA from its surrounding. It is a key step in their process of rapidly evolving new traits, including troublesome drug resistance. The new methods developed by the researchers provided them with the ability to catch this mechanism on film.
The class of drugs currently prescribed to treat male erectile dysfunction has the potential to be repurposed for use in cancer treatment. Cancer specialists would like to prescribe existing medications like Viagra and Cialis since they are affordable and approved for use, thus save significant research money otherwise spent on expensive drug discovery.
Stanford University bioengineers have found a way to produce noscapine, a non-narcotic cough suppressant with potential anticancer properties, in brewer’s yeast. The researchers inserted 25 foreign genes into the yeast to turn it into an efficient factory for producing the drug that naturally occurs in opium poppy.
Commonly prescribed drugs called fluoroquinolones, the fourth-most used class of antibiotics in the US, have been shown to cause rare, disabling side effects. Patients have experienced pain in tendons, joints and muscles, neurological and psychological difficulties. Researchers now have a few theories why such symptoms may occur.
For the second year in a row, life expectancy in the United States declined due to an opioid crisis. Scientists have high hopes for a new opioid vaccine developed by the US military, that shows promising results in mice and rats.
Researchers at Harvard University developed an effective personalized cancer vaccine that seems to have prevented early tumour relapse in 12 skin cancer patients. The vaccine targeted 20 tumour-specific proteins unique to each of the patients enrolled, keeping all free of cancer over 2 years after the trial.