Tag : genome

DNA

Scientists Squeeze Entire Yeast Genome into Just One Chromosome

Two separate research groups used CRISPR gene editing to fuse entire sets of brewer’s yeast chromosomes together, resulting in two strains with just one and two chromosomes. Surprisingly, the changes had little effect on most functions of the yeast. Their findings could be monumental to the study of chromosomes and why their numbers vary from species to species.

mice

Controversial CRISPR “Gene Drives” Tested in Mice

Researchers from the University of California tested gene-drive technology in mice. This controversial application of CRISPR, capable of altering the genomes of entire species, has been applied to mammals for the first time. Although the developed technology has a long way to go before being used for pest control in the wild, it could be useful in basic research.

mosquito malaria

Engineered Shrub Boosts Malaria Drug Artemisinin Yield

Researchers from China have modified an Artemisia annua genetic sequence to produce a higher level of a potent antimalarial compound, artemisinin. The group identified genes involved in making artemisinin in Artemisia annua and altered their activity to produce three times more drug than usual. Their work will help to meet the large global demand for artemisinin, which is also used to treat cancer, tuberculosis, and diabetes.

DNA molecular scissors

New Cpf1 Molecular Scissors to Take Genomic Editing to the Next Level

CRISPR (Clustered Regularly Interspaced Palindromic Repeats) gene editing technology allows permanent modification of genes within organisms. It is considered a breakthrough in biotechnology ever since its discovery.  Researchers from the University of Copenhagen (Denmark), led by Spanish researcher Guillermo Montoya, now went one step further. They discovered how Cpf1, a new type of molecular scissors, unzip and cleave DNA.